Download Understanding Ageing (Developmental and Cell Biology Series) by Robin Holliday PDF

By Robin Holliday

This e-book offers a very novel method of knowing getting older: it explains either why getting older exists in animals and reports our present figuring out of it on the organic point. Dr. Holliday argues that a lot examine has to be performed at the mobile and molecular elements of getting older if the beginning of age-related ailments is to be understood. In making this argument, the writer attracts on fabric from a variety of disciplines, together with wide biomedical information regarding age-related illness in people. This thought-provoking e-book will attract all scholars and researchers who're drawn to getting older, whether or not they are operating within the scientific or uncomplicated examine sphere.

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Although some repair is possible in major vessels, this in turn leads to scar tissue, which is itself imperfect. The basic problem is that the lumen of an artery is simply in the wrong location for effective repair. The problem with both the brain and the vascular system is that continuous function is necessary. When a working machine is to be repaired, it is first stopped, and restarted after the repairs are completed. This is not possible for vital organs in continual use. It is possible to envisage a permanent vascular system, but it would be very different from the one that evolved.

TOXIC CHEMICALS AND DETOXIFICATION One of the main defences plants have against herbivorous animals is the production of toxic chemicals in the leaves or other parts of the plants. It is now clear that a considerable proportion of plant metabolism (collectively known as 'secondary metabolism') is devoted to the synthesis of these chemicals. A large range of toxins exist, some directed against insects, some against mammalian herbivores, and so on. In response, animals have evolved specific detoxification mechanisms over a long period of evolutionary time.

Adult Drosophila has dividing cells in its germ line, but The evolved anatomical and physiological design of mammals 15 almost all its other cells are post-mitotic. Like nematodes, flies have a very well-defined lifespan, so not surprisingly both have been extensively used in experimental studies on ageing. It is unrealistic to expect non-dividing, metabolically active cells to survive indefinitely. There are many reasons why cells might die, and these are discussed elsewhere in this book. It is sufficient to stress here that macromolecular systems are not in equilibrium or a steady state.

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