Download Pharmaceutical Technology. Controlled Drug Release, by MICHAEL H.RUBINSTEIN, James I. Wells, Michael H. Rubinstein PDF

By MICHAEL H.RUBINSTEIN, James I. Wells, Michael H. Rubinstein

Extends the options of quantity 1 to incorporate drug homes, layout and optimization, coating and the influence of meals and pharmacokinetics. This quantity additionally displays the growing to be curiosity in biodegradable polymers in oral and topical formulations and using sterile implants.

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The matrix surface becomes porous, giving it a spongy texture. The ionic strengths which caused disintegration varied according to the salt used. 0 of sodium chloride was required to effect disintegration. Since the disintegration of the tablets can be explained by the salts decreasing the cloud point then their efffect on disintegration should also follow the lyotropic series. On this basis sodium salts appear anomalous since they should produce lower disintegration times than potassium salts.

The speed of the machine was adjusted to one tablet s−1. 8mm perforations for the final milling. MATRIX FORMULATIONS [CH. 4 45 (4) Grinding and separation of the particle size ranges in a Russell vibratory machine (Russell Finex, London and New York). (5) Lubrication for 3 min. (6) Final compression on the same instrumented tablet machine to obtain a 400 mg tablet. TESTS PERFORMED Powder test Powder flow rate was determined using a glass funnel. Engelsmann AG) tapping volume meter [14–16]. Physics of compression In sampling ten tablets, the following parameters were studied: the lubrication index (R), the ejection force (Fc), the residual force (Fr) and the cohesion index (CI=ratio of the pressure applied to the upper punch and the tensile strength) proposed by Guyot [17].

Pharm. , 55, 974 (1966). Christenson, J. Pharm. , 51, 164 (1968). Çapan, Drug Dev. Ind. , 15, 927 (1989). Higuchi, J. Pharm. , 52, 1145 (1963). Higuchi, J. Pharm. , 51, 802 (1962). Peppas, Pharm. Acta. , 60, 110 (1985). Carstensen, Int. J. , 2, 307 (1979). MATRIX FORMULATIONS [CH. 3 41 Fig. 5–4 kp, ○, 7. 5–8 kp. Hncal, Pharm. , 51, 443 (1989). Lordi, J. Pharm. , 57, 1292 (1968). Higuchi, J. Pharm. , 54, 1459 (1965). Higuchi, J. Pharm. , 55, 1224 (1966). Higuchi, J. Pharm. , 55, 1235 (1966). Peppas, J.

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