By Baetge, Emmanuel E.; Dhawan, Anil; Prentice, Andrew
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Additional info for Next-generation nutritional biomarkers to guide better health care
J Clin Invest 2008;118:1322–1329. 3 Bates CJ: Diagnosis and detection of vitamin deficiencies. Br Med Bull 1999;55:643–657. 4 Pasricha SR, Atkinson SH, Armitage AE, et al: Expression of the iron hormone hepcidin distinguishes different types of anemia in African children. Sci Transl Med 2014;6: 235re3. 5 Atkinson SH, Armitage AE, Khandwala S, et al: Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children. Blood 2014;123:3221–3229.
Example of treatment of T2D patients with a very low caloric diet (VLCD) or physical exercise. Research showed that T2D patients react differently to these treatments. When insulin resistance is mainly localized in muscles, physical exercise has a higher and faster improvement in health as compared to VLCD. In patients with insulin resistance mainly located in the liver, VLCD can normalize the glucose metabolism already within 8 weeks. However, when β-cell capacity is not sufficient enough it is known that the patient has neither benefit from VLCD nor from physical exercise [9–12].
One can, for example, refine the network to show only molecular interactions between a list of differentially expressed genes (and their encoded products) or view all potential interactors regardless of whether they are differentially expressed. This can aid in the identification of important nodes that may not be regulated transcriptionally or which are expressed at an earlier or later time. Each network can be interactively visualized at the click of a button using the Cerebral plug-in for Cytoscape, which has been developed as part of the InnateDB project, and generates biologically intuitive, pathway-like layouts of networks .