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By Fu, Cynthia H. Y.

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Since the responses need to be singularly and unambiguously assigned to each event, the interstimulus time needs to be at least as long as the typical width of the BOLD response curve (8–10 s). Therefore, these experiments need to be very long, and become prohibitively long for certain subject populations such as children and the elderly. When using a constant interstimulus interval (ISI), such as might be used in a block-design paradigm, the optimal ISI is about 10–12 s. Dale101 showed that responses to visual stimuli, presented as rapidly as once every 1 s, can be adequately separated using overlap correction methods.

27. Kim S-G, Ugurbil K. Comparison of blood oxygenation and cerebral blood flow effects in fMRI: estimation of relative oxygen consumption change. Magn Reson Med 1997; 38: 59–65. 28. Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, Pike GB. Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: the deoxyhemoglobin dilution model. Magn Reson Med 1999; 42: 849–63. 29. Hoge RD, Atkinson J, Gill B, Crelier GR, Marrett S, Pike GB. Stimulus-dependent BOLD and perfusion dynamics in human V1.

44 FUNCTIONAL NEUROIMAGING 6. Gati JS, Menon RS, Ugurbil K, Rutt BK. Experimental determination of the BOLD field strength dependence in vessels and tissue. Magn Reson Med 1997; 38: 296–302. 7. Noll D. 1, 6/21/01). pdf. 8. Lauterbur PC. Imager formation by induced local interactions. Examples employing nuclear magnetic resonance. Nature 1973; 242: 190–1. 9. Mansfield P, Grannell PK. Diffraction and microscopy in solids and liquids by NMR. Phys Rev B 1975; 12: 3618–34. 10. Cohen MS, Weisskoff RM. Ultra-fast imaging.

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