Download Macrophages and Lymphocytes: Nature, Functions, and by R. R. Strauss (auth.), Mario R. Escobar, Herman Friedman PDF

By R. R. Strauss (auth.), Mario R. Escobar, Herman Friedman (eds.)

The Reticuloendothelial (RE) Society, that is enthusiastic about advd~cement of data in regards to the many diversified capabilities of RE cells, organizes nationwide and foreign conferences and publishes a systematic magazine. The VIII foreign Congress of the RE Society was once held in Jerusalem, Israel, June 18-23, 1978. The Congress had as its clinical objec,tive quite a lot of sub­ jects in regards to the RE process, specially as relating to macro­ phage functionality and interplay with lymphocytes. Emphasis of the Congress used to be put on the character and serve as of macrophages and different cells of the RE approach on the subject of immune responses, anti-infectious job, tumor immunity, autoimmunity, and trans­ plant rejection. The secretion of soluble elements through rnacrophages and lymphocytes and the mode of motion of those components on different cells used to be under pressure. in the course of the Congress a few dialogue was once entertained about the controversy as to what constitutes the "RE method" in keeping with se. a few investigators believe that the phagocytic job of rnacrophages is an important point of the RE method enjoying additionally an incredible position in lots of parameters of immunity. Mononuclear phagocytes contain tissue rnacrophages in addition to cir­ culating monocytes and their precursors. even though phagocytosis is a big useful job of those cells, it is just among the activities.

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5 ~g/ml) resulted in marked suppression of the PFC response. 01) by Student's t test. The optimal time of addition of DOG for in vitro immunosuppression appears to be between 2 and 3 hr after addition of the SRBC antigen. These data are shown in Table III. There is little or no suppression of the PFC response if DOG is added 48 or 72 hr after addition of antigen (data not 6 R. R. 7 aValues are expressed as the mean + SEM of 3 cultures TABLE III Effect of Time of Addition of 2-Deoxyglucose on In vitro PFC Response to Sheep Erythrocytes Dexoyglucose + + + + + + Time of Addition a 0 + 1 + 2 + 3 + 5 +24 hr hr hr hr hr PFC/l0 6 Cells 1250 643 659 669 973 871 1067 % Change - 49 47 46 22 30 15 a 10 )Jg/cu1ture of 2-deoxyg1ucose was added when indicated shown).

LM Antimycin A, the generation of H20 2 is unaffected under these conditions. This means that phagocytosis of particles is not needed for the occurrence of the respiratory burst in monocytes. Apparently, attachment of the particles to the monocytes provides sufficient stimulus for the activation of the oxygen-reducing system in these cells. Similar observations have been made with neutrophils (1). J 30 tine (ri'I) o 10 20 30 tine (min) Fig. 1. Effect of Antimycin A on oxygen consumption and hydrogen peroxide release by zymosan-stimulated cells.

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