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By Sheldon Spector

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Haddad EB, Roussel J, Mak JCW, Barnes PJ. Long-term carbachol treatment induced down-regulation of muscarinic M 2 receptors but not m2 receptor mRNA in a human lung cell line. Br J Pharmacol 1995; 116:2027–2032. Roussel J, Haddad EB, Mak JCW, Webb BL, Giembycz MA, Barnes PJ. Betaadrenoceptor mediated down-regulation of M 2 muscarinic receptors: role of cyclic adenosine 5′ monophosphate-dependent protein kinase. J Mol Pharmacol 1996; 49:629–635. Yang CM, Chou SP, Sung TC. Muscarinic receptor subtypes coupled to generation of different second messengers in isolated tracheal smooth muscle cells.

112. 113. 29 Fernandes LB, Fryer AD, Hirschman CA. M 2 muscarinic receptors inhibit isoproterenol-induced relaxation of canine smooth muscle. J Pharmacol Exp Ther 1992; 262:119–126. Haddad EB, Roussel J, Mak JCW, Barnes PJ. Long-term carbachol treatment induced down-regulation of muscarinic M 2 receptors but not m2 receptor mRNA in a human lung cell line. Br J Pharmacol 1995; 116:2027–2032. Roussel J, Haddad EB, Mak JCW, Webb BL, Giembycz MA, Barnes PJ. Betaadrenoceptor mediated down-regulation of M 2 muscarinic receptors: role of cyclic adenosine 5′ monophosphate-dependent protein kinase.

Vasoactive intestinal polypeptide (VIP) in vasomotor rhinitis. Clin Biochem 1983; 11:425. 24 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. Mullol and Baraniuk Stjarne P, Lacroix JS, Anggard A, Lundberg JM. Compartment analysis of vascular effects of neuropeptides and capsaicin in the pig nasal mucosa. Acta Physiol Scand 1991; 141:335. Barnes PJ, Nadel JA, Roberts JM, Basbaum CB: Muscarinic receptors in lung and trachea: autradiographic localization using [3 H]quinuclidinyl benzilate.

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