By Ole G. Mouritsen, Luis A. Bagatolli
The current ebook offers a multi-disciplinary viewpoint at the physics of existence and the actual position performed via lipids (fats) and the lipid-bilayer part of mobile membranes. The emphasis is at the actual houses of lipid membranes noticeable as smooth and molecularly dependent interfaces. via combining and synthesizing insights received from a number of contemporary stories, an try out is made to explain what membrane constitution is and the way it may be quantitatively defined. moreover, it's proven how organic functionality mediated by way of membranes is managed by means of lipid membrane constitution and association on size scales starting from the scale of the person molecule, throughout molecular assemblies of proteins and lipid domain names within the diversity of nanometers, to the scale of complete cells. functions of lipids in nanotechnology and biomedicine also are described.
The first variation of the current ebook used to be released in 2005 whilst lipidomics used to be nonetheless a great deal an rising technological know-how and lipids approximately to be well-known as being as very important for all times as proteins, sugars, and genes. This considerably improved and revised variation takes under consideration the super quantity of information won over the last decade. additionally, the e-book now contains extra educational fabric at the biochemistry of lipids and the rules of lipid self-assembly.
The booklet is geared toward undergraduate scholars and younger examine staff inside of physics, chemistry, biochemistry, molecular biology, food, in addition to pharmaceutical and biomedical sciences.
Read Online or Download Life - As A Matter of Fat: Lipids in a Membrane Biophysics Perspective (2nd Edition) (The Frontiers Collection) PDF
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Extra resources for Life - As A Matter of Fat: Lipids in a Membrane Biophysics Perspective (2nd Edition) (The Frontiers Collection)
Louvi A. and Artavanis-Tsakonas S. (2006) Notch signalling in vertebrate neural development. Nat Rev Neurosci 7, 93–102. 28 GOLDE ET AL. , Bolduc M. and Leclerc D. (2005) Signal peptide peptidase promotes the formation of hepatitis C virus non-enveloped particles and is captured on the viral membrane during assembly. J Gen Virol 86, 3055–3064. , Wen P. , Siman R. and Robakis N. K. (2003) A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations.
2005; Krawitz et al. 2005). No mouse knockouts have been reported. These studies suggest that SPP and its homologs have important functional roles in development. In C. elegans, deficiency of ce-imp-2 (a SPP like gene) causes a severe developmental phenotype (Grigorenko et al. 2004). The effect of knockout of the two other C. elegans SPP homologs was not reported. Drosophila deficient in one of two SPP genes (CG11840) had defective trachea and died as larvae (Casso et al. 2005). In Zebrafish, when either the SPP or SPPL3 homologs were knocked down, an embryonic lethal phenotype was observed, with 24 GOLDE ET AL.
2004). Assembly of these -secretase complexes is tightly regulated in a coordinated manner. The available data suggest a model for -secretase complex assembly where first NCT and APH-1 form an initial complex (LaVoie et al. 2003). In the next step of assembly PS joins this NCT/APH-1 assembly intermediate to form a ternary complex. Finally PEN-2 assembles to trigger PS endoproteolysis into its NTF and CTF (Takasugi et al. 2003). Following these assembly steps which take place at the endoplasmic reticulum (Kim et al.