By Hiroshi Nagasawa (auth.), Benjamin S. Leung Ph.D. (eds.)
The idea that hormones impression tumor progress originated in 1889 with the thought of Albert Schinzinger who prompt that breast melanoma is expounded to the ovaries. a number of years later, Sir George Beatson saw that remission of disseminated breast melanoma should be completed in premenopausal sufferers by way of appearing bilateral oophorectomy. due to the contri butions of Hedley Atkins, Charles Huggins and others, additive and ablative hormonal cures were normal for the remedy of complicated breast cancers for numerous a long time. version platforms to check the consequences of hormones on development and regression of breast tumors were to be had for a few years; despite the fact that, the complexities of the hormonal setting have rendered in vivo experiences tricky in guy and experimental animals. lately, the supply of long term cultures of breast melanoma cells has encouraged many investigators to take advantage of those phone strains to solve the mechanisms of hormone motion. end result of the severe variety and complexity of advances concerning the endocrinology of the breast and breast cancers, a multi-authored evaluate was once deemed beneficial. it's been pleasurable to obtain contributions from many famous students. In quantity I of this monograph, the effect of steroid hormones and their antagonists upon general and neoplastic tissues of the mammary gland are offered. In quantity II, the consequences of peptide and different hormones are reviewed.
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Sample text
Importance of mammary gland DNA synthesis on carcinogen-induced mammary tumorigenesis in rats. Cancer Res 36: 2223-2226, 1976. 41. Nagasawa H, Yanai R, Taniguchi H. Reduction by pituitary grafts of mammary tumor age. Its variability in a high mammary tumor strain of mice. Effects of mammary DNA synthesis. Eur J Cancer 12: 1017-1019, 1976. 42. Nagasawa H, Yanai R, Taniguchi H, Tokuzen R, Nakahara W. Two-way selection of Swiss albino mice for mammary tumorigenesis: Establishment of new two strains (SHN and SLN).
VanderLaan WP. Influence of nurslng on the release of prolactln and GH in mice with high and low incidence of mammary tumors. Endocrinology 95: 947-54, 1974. 49. Sinha YN, Salocks CB, VanderLaan WP. Prolactin and growth hormone levels in different inbred strains of mice: Patterns in association with estrous cycle, time of day, and perphenazine stimulation. Endocrinology 97: 1112-1122, 1975. 50. Sinha YN, Salocks CB, VanderLaan WP. Circulating levels of prolactin and growth hormone and natural incidence of mammary tumors in mice.
Int J Cancer 6: 488-495, 1970. 27. Nagasawa H, Yanal R. Quantitative participation of placental mammotropic hormones in mammary development during pregnancy in mice. Endocrinol Jpn 18: 507-510, 1971. 20 28. Nagasawa H, Yanai R. Effect of human placental lactogen on growth of carcinogen-lnduced mammary tumors in rats. Int J Cancer 11: 131-137, 1973. 29. Nagasawa H, Yanai R. Some discrepancies between the use of DNA synthesis and wholemount preparations as indices of mammary gland response to pituitary mammotrophin.
