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By Dr Christina Bolander-Gouaille, Dr Teodoro Bottiglieri (auth.)

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Additional resources for Homocysteine: Related Vitamins and Neuropsychiatric Disorders

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Stroke is the most obvious example. The proposed vascular pathophysiology is therefore also briefly summarised. The vascular mechanisms have been extensively studied both in vitro and in vivo. In vitro studies suggest that Hey can induce direct damage to endothelial cells, increased platelet activity, pro-coagulant effects, increased collagen synthesis, and enhanced proliferation of smooth muscle cells. Mild hyperhomocysteinemia induced in animals, mostly by dietary means, has been accompanied by impaired vasomotor regulation and 36 Homocysteine Related Vitamins and Neuropsychiatric Disorders antithrombotic function, as well as subclinical or clear atherothrombotic lesions, lipid peroxidation, enhanced neutrophil-endothelial interactions, and pronounced intimal hyperplasia.

Mean levels of 383 nmollL for patients and 680 nmollL for controls are found. , 1997). SAM also has an antidepressant effect. A meta-analysis of the effect as an antidepressant led to the conclusion that SAM has an effect comparable to that of standard tricyclic antidepressants (Bressa GM, 1994). , 2000). An increased level of SAH as a consequence of increased tHey, may, by a competitive inhibition, impair methylation reactions. , 2001). SAM may also have an indirect antioxidative effect. , 2000).

In vitro studies suggest that Hey can induce direct damage to endothelial cells, increased platelet activity, pro-coagulant effects, increased collagen synthesis, and enhanced proliferation of smooth muscle cells. Mild hyperhomocysteinemia induced in animals, mostly by dietary means, has been accompanied by impaired vasomotor regulation and 36 Homocysteine Related Vitamins and Neuropsychiatric Disorders antithrombotic function, as well as subclinical or clear atherothrombotic lesions, lipid peroxidation, enhanced neutrophil-endothelial interactions, and pronounced intimal hyperplasia.

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