By Albert Weissman (auth.), Harbans Lal (eds.)
As person who has long past down the wayward direction from "pure" natural chemistry to biochemistry to pharmacology, i used to be now not fairly ready to move all of the approach - into the sphere of discriminable stimuli. The organizer of the symposium on discriminable stimuli brought on by way of medicines, Dr. Harbans Lal, did seduce me into attending. Having misplaced my behavioral virginity, I now stare with open eyes on the box. One merchandise particularly at this assembly exemplifies to me the facility of such strategies. Dr. Albert Weissman pointed out the matter he tackled with getting rats to discriminate among saline and dilute strategies of aspirin. below traditional conditions, the animals couldn't practice this job. even though, if the animals have been sensitized via injection of prostaglan din into their foot pads, then they have been in a position to discriminating even very dilute strategies of aspirin. In a feeling, Al had created a version of the human arthritic who can jolly good inform in case you have given him an aspirin or a salt pill. The reader of this quantity will locate it a very good advent to the usage of discriminable stimuli precipitated through medicines. After a preface by means of the organizer, specialists speak about uncomplicated ideas in separate chapters. this kind of chapters locations emphasis at the medications; the opposite areas emphasis at the prompted cues and states.
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Extra info for Discriminative Stimulus Properties of Drugs
J. Pharmacol. Ther. 185: 101-107. 1973. WINTER. J. : The effe cts of 3. 4 -dimethoxyphenylethylamine in rats trained with mescaline as a discriminative stimulus. Ther. 189: 741-747. 1974. WINTER. J. : The stimulus properties of morphine and ethanol. Psychopharmacologia 44: 209-214. 1975. WOODARD. T. AND BITTERMAN. : A discrete-trials/ fixed -interval method of dis crimination training. B eha v . Res. Methods Instrum. 6: 389-392. 1974. 1. 02881 1. arily used to relieve pain. any new drugs are synthetic.
The first observing response of each trial terminates the white noise; the houselight remains on until the appropriate choice response is made to terminate the trial. 5 second pulses with 2. 5 seconds between pulses for the duration of the trial. The first trial of every session se rves as a "warm-up" and is not recorded. Once the rats are trained to a crite rion of 18 out of 20 correct responses in 4-6 sessions, the test sessions are initiated when a test drug or dose is substituted for the training drug.
Animals Male hooded rats of the Long-Evans strain weighing 200-250 g at the start of the experiment are placed in single cages and adapted to consume their total daily ration of food (12-18 grams) within a few hours each afternoon (2-5 PM). Water is made continuously available. Nearly 2/3 of the rats adapt to this feeding schedule. The rats which do not adapt to this schedule within a week and begin to lose weight are discarded. The rats are housed in a room thermostatically maintained at 21°C.