By P. Giannakopoulos, P.R. Hof, J. Bogousslavsky
This e-book summarizes the newest advances in neurobiology, diagnostic ways and therapeutics of the main dementing health problems comparable to Alzheimer’s disorder, frontotemporal dementia, Lewy physique disorder, and vascular dementia. In a succinct, sensible and entire demeanour, it offers an up to date view of the issues more likely to be encountered in a regular perform. each one part is targeted on an enormous kind of dementia and is equipped following an identical scheme reviewing the pathophysiology of the affliction, its diagnostic demanding situations, its attribute neuroimaging good points, healing interventions and sufferer administration matters. keeping off an overspecialized procedure, the publication bridges the distance among scientific perform, complex imaging, fresh therapeutics and uncomplicated sciences. therefore, it serves as a very good advisor for psychological well-being pros operating within the box of dementia in addition to fundamental care physicians and scholars.
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Extra info for Dementia in Clinical Practice (Frontiers of Neurology and Neuroscience)
27 Visser PJ, Brodaty H: MCI is not a clinically useful concept. Int Psychogeriatr 2006;18:402–409. 28 Dierckx E, Engelborghs S, De Raedt R, De Deyn PP, Ponjaert-Kristoffersen I: Mild cognitive impairment: what’s in a name? Gerontology 2007;53:28– 35. 29 Missonnier P, Gold G, Fazio-Costa L, Michel JP, Mulligan R, Michon A, Ibáñez V, Giannakopoulos P: Early event-related potential changes during working memory activation predict rapid decline in mild cognitive impairment. J Gerontol A Biol Sci Med Sci 2005;60:660–666.
Unlike fibrillar amyloid deposits that are poorly or not related to the dementia severity, the use of this method documented that total neurofibrillary tangles and neuron numbers in the CA1 field are the best correlates of cognitive deterioration in brain aging. Loss of dendritic spines in neocortical but not hippocampal areas has a modest but independent contribution to dementia. In contrast, the importance of early dendritic and axonal tau-related pathologic changes such as neuropil threads remains doubtful.
4 Hanninen T, Hallikainen M, Tuomainen S, Vanhanen M, Soininen H: Prevalence of mild cognitive impairment: a population-based study in elderly subjects. Acta Neurol Scand 2002;106:148–154. Ibáñez · Deiber 5 Markesbery WR, Schmitt FA, Kryscio RJ, Davis DG, Smith CD, Wekstein DR: Neuropathologic substrate of mild cognitive impairment. Arch Neurol 2006; 63:38–46. 6 Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J, Delacourte A, Galasko D, Gauthier S, Jicha G, Meguro K, O’Brien J, Pasquier F, Robert P, Rossor M, Salloway S, Stern Y, Visser PJ, Scheltens P: Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria.