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By A. S. Troelstra

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Baruj Benacerraf receiving the Nobel Prize from the King of Sweden in 1980. (Courtesy of the Dana-­Farber Cancer Institute) in New York City. They w ­ ere Baruj Benacerraf, at NYU, and Henry Kunkel, at the Rocke­fel­ler University. 5 This represented another of those fortunate events that determine the course of a life. 2), to be the chairman of the department of pathology at the Harvard Medical School, and to be the president of the Dana-­Farber Cancer Institute at Harvard. However, these honors and responsibilities lay in the ­future.

36 Immunology Baruj was born in Caracas, Venezuela, of Sephardic Jewish parents. His ­father was a successful businessman who had established an import com­ pany in Venezuela and set up a branch in France, moving with his f­ amily to Paris when Baruj was five. The Benacerrafs lived in Paris u ­ ntil 1939 when the coming of the war impelled Baruj’s f­ ather to take the f­ amily back to Venezuela. Their stay in Caracas was brief because it was a priority that Baruj complete his education. The Benacerrafs came to New York City where Baruj first attended the École Française and then Columbia University.

Vaccination against smallpox provides robust protection against infection with the smallpox virus, but it does not offer protection against infection with measles virus; vaccination against measles virus does not protect us against the smallpox virus. One way vaccines offer protection is by causing antibodies to form that react with and neutralize or lead to the destruction of the disease-­causing microbe. 3 Vaccination also prepares the individual to make a secondary antibody response on infection with the microbe bearing the antigen or on rechallenge with the antigen or antigens that make up the vaccine.

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