By Chioma M. Okeoma
This publication describes the molecular biology, pathogenesis, epidemiology, and capability techniques for keep an eye on of chikungunya virus (CHIKV) an infection. It deals perception into the constitution and capabilities of CHIKV proteins as they relate to host reaction, interplay with the arthropod vector, and vaccination. an in depth account of either the epidemiological outlook and the medical syndrome of CHIKV an infection is equipped. The complicated host-virus interplay and the signaling pathways that mediate such interactions also are coated. during the booklet, pics and charts are used to supply stimulating dialogue on vital findings within the box of chikungunyalogy. The chapters are written with an international standpoint by way of specialists of CHIKV from all over the world. This venture is principally major provided that CHIKV is a pathogen of globally public health and wellbeing main issue. even supposing the presence of CHIKV an infection isn't worldwide but, around the globe dissemination is expected sooner or later due mostly to the inability of powerful treatment/therapy, effective keep an eye on of transmission, and information approximately mechanisms of pathogenesis. also, globalization of CHIKV relies on its mode of dissemination (mosquito vector) and move border go back and forth and migration.
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Extra info for Chikungunya Virus: Advances in Biology, Pathogenesis, and Treatment
J Immunol 156(3):1138–1142 Ozden S, Huerre M, Riviere JP, Coffey LL, Afonso PV, Mouly V, de Monredon J, Roger JC, El Amrani M, Yvin JL et al (2007) Human muscle satellite cells as targets of chikungunya virus infection. PLoS One 2:e527 Pal P, Dowd KA, Brien JD, Edeling MA, Gorlatov S, Johnson S, Lee I, Akahata W, Nabel GJ, Richter MK, Smit JM, Fremont DH, Pierson TC, Heise MT, Diamond MS (2013) Development of a highly protective combination monoclonal antibody therapy against chikungunya virus.
Other studies have also demonstrated that IRF3/IRF7- deficient mice developed hemorrhagic fever and shock after CHIKV infection (Rudd et al. 2012). Therefore, young age and inefficient type-I IFN signaling are risk factors for severe CHIKV disease. Host Response and Mechanisms of Subversion of Chikungunya 25 Adaptive Immune Response and Protection CHIKF leads to a protective adaptive immunity. The establishment of anti-CHIKV immune response after a primary infection could confer complete protection against reinfection.
2007; Powers and Logue 2007; Suhrbier and La Linn 2004). It is characterized by severe joint pain due to inflammation and tissue destruction caused by inflammatory cytokines such as IL-1β, IL-6, and TNF-α as reported in CHIKF patients (Ng et al. 2009; Hoarau et al. 2010; Chow et al. 2011). Prostaglandins have also been shown to be highly expressed by CHIKV-infected fibroblasts (Fitzpatrick and Stringfellow 1980) and may contribute to mechanisms of nociceptor activation and sensitization as described in osteoarthritis joints (Fitzpatrick and Stringfellow 1980; Malfait and Schnitzer 2013).