Download Caloric restriction: a key to understanding and modulating by E. J. Masoro PDF

By E. J. Masoro

For a few years, it's been identified that once rats and mice are given a discounted quantity of nutrients, their existence span is elevated they usually stay fit and full of life at complicated ages.

what's the reason behind this alteration within the traditional trend of getting older? The facts is overwhelming that the existence extension effects from a slowing of getting older procedures. And the issue in charge is the reduce in caloric consumption. the most obvious query: How does this issue paintings? a very good query - and the explanation that study at the anti-aging motion of caloric limit is this day some of the most studied study parts in organic gerontology. For it truly is felt that if the organic mechanisms of the anti-aging motion of caloric limit could be exposed, we'd achieve an realizing of the fundamental nature of getting older tactics, which might, in flip, yield attainable interventions in human getting older. This e-book goals to supply the growing to be variety of researchers during this box (faculty, postdoctoral trainees, and graduate scholars) with an in depth wisdom of what's identified approximately caloric restrict in the body of gerontology, in addition to insights on way forward for this box.

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Extra info for Caloric restriction: a key to understanding and modulating aging

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Gene expression . . . . . . . . . Mitochondrial function . . . . . . . Membrane structure and function . . . Protein structure, function, and turnover Cell proliferation . . . . . . . . . Apoptosis . . . . . . . . . . . Cellular signal transduction . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

On the other hand, too little apoptosis can lead to an accumulation of damaged cells, hyperplasia, and/or neoplasia. Warner et al. (1995) hypothesized that CR’s anti-aging action could be due to the upregulation of apoptosis. Molecular and Cellular Biology 39 Figure 3-10. The effects of 14 weeks of CR on cell proliferation in the glandular stomach, duodenum, and forestomach of male 28-month-old F344 rats. The authors designate 14 weeks of CR as diet restricted. 008 Note: Data from James Muskhelishvilli, 1994.

1996). Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence. Proc. Natl. Acad. , USA 93: 485–490. , Nazir, M. & Ward, W. F. (1996). Alteration of rat liver 20S proteosome activities by age and food restriction. J. : Biol. Sci. 51A: B316–B322. Sohal, R. S. & Dubey, A. (1994). Mitochondrial oxidative damage, hydrogen peroxide release, and aging. Free Radic. Biol. Med. 16: 621–626. Sohal, R. , Forster, M. , & Lal, H. (1994a). Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice.

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