By John Caldwell
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Extra info for Biological Basis of Detoxication
The primary selectivity denoted by S is determined, in fact, by the sum of selectivities of each cytochrome-dependent reaction. Primary selectivity (S) = axrxPx + a2r2P2 + · · •/ßi'"i + Wi + (1) In Eq. (1), rl9 r2, and so on are the total rates of carcinogen metabolism at the separate forms, and Pl9 P2, and so on are the respective fractions metabolized to a carcinogenic precursor. 2. 43 Integration of Xenobiotic Metabolism The partition of the metabolism of precursor P between activation to an electrophile U and detoxication can be represented by the diversionary detoxication factor D.
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A. (1977). Thioacetamide-induced hepa tic necrosis. I. Involvement of the mixed-function oxidase enzyme system. J. Phar macol. Exp. Ther. 200, 439-448. 128. Porter, W. , Gudzinowicz, M. , and Neal, R. A. (1979). Thioacetamide-induced hepatic necrosis. II. Pharmacokinetics of thioacetamide and thioacetamide S-oxide in the rat. J. Pharmacol. Exp. Ther. 208, 386-391. 129. Boyd, M. , and Neal, R. A. (1976). Studies on the mechanism of toxicity and of development of tolerance to the pulmonary toxin, α-naphthylthioureau (ANTU).