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Extra info for Biochemical and Neurophysiological Correlation of Centrally Acting Drugs. Second International Pharmacological Meeting
SPIEGEL, E . A. and W Y C I S , H . T. (1961) Stimulation of brainstem and basal ganglia in man. Sympos. University of Houston, Texas, April 1956. I n Sheer, D. , E d . Electrical Stimulation of the Brain, Austin, Univ. of Texas Press. SPIEGEL, E . A. and SZEKELY, E . G. (1961) Prolonged stimulation of t h e head of t h e caudate nucleus. A. Arch. Neurol. 4, 55—65. SPIEGEL, E . A. and W Y C I S , H . T. (1962) Stereoencephalotomy I I . Grune & Stratton, New York. SPIEGEL, E . , SZEKELY, E . G. and K I R B Y , A.
SHIMAZU, H . , FTJJTTA, Y . , NAGAO, T. a n d NAGAHATA, M. (1960) Procaine-oil-wax pallidotomy for double athetosis and spastic states in infantile cerebral palsy. Neurology, 10, 61 — 69. NASHOLD, B . , H A N B E R Y , J . a n d O L S Z E W S K I , J . (1955) Observations on t h e diffuse thalamic projections. EEO Clin. Neurophysiol. 7, 609 — 620. NAUTA, W . J . H . and MEHLER, W . (1961) Some efferent connections of t h e lentiform nuclei. Anat. Rec. 139, 260. 30 E. A. SPIEG-EL NAUTA, W . J .
Behavioural Effects (a) Motor activity and aggressiveness (Table 1). When L - D O P A is injected intraperitoneally in doses of 100 mg/kg (Sourkes, 1961) or intravenously in somewhat larger doses (Wende and Spoerlein, 1962), the animals no longer congregate in a pile, as they do normally, but adopt an aggressive stance in isolated positions around the perimeter of the cage. From time to time they attack one another. With the larger doses of DOPA, the mice exhibit catatonic postures, piloerection, salivation, ejaculation, Straub tailraising, and a "fear" reaction.