Download Anarchist Arsenal: Improvised Incendiary And Explosives by David Harber PDF

By David Harber

Written by way of a former EOD professional, this e-book fills within the gaps left via different explosives manuals, together with many units and methods that experience by no means seemed in print. targeted formulation, diagrams and directions for Semtex, C-4, land mines, automobile bombs, mollies, FAEs and extra. for info reasons in basic terms.

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It is now believed that enzymes which cause the detoxification of chemicals are only rarely the same enzymes which cause activation. Evidence is accumulating that cytochrome P-450 is generally involved in detoxification reactions, whereas activation is usually caused by cytochrome P-448 (Parke and loannides, 1981 a). Since there are pronounced species differences in the predominance of these enzymes (both microsomal and cytosolic), major differences in the ratio of detoxification/ activation ofpre-carcinogens may occur in different species.

The reason for the proportionality of the activity of mixed function oxidases to body weight is probably that it is dependent on other factors besides the concentration of tissue oxygen. , 1967). Toxicity of oxygen in the tissues is another factor related to mixed function oxidase activity which should be considered. The free radical theory of oxygen toxicity attributes the damaging effects of hyperoxia to the production of reactive species like the singlet oxygen, hydroxyl radical and superoxide anion.

Synergism and Antagonism 47 In some cases, the mechanism involved may be more complex. For instance, phenobarbital antagonizes the anti-tumor and the immunodepressant effect of cyclophosphamide. , 1975). Antagonism mayaiso result from inhibition of metabolism of a drug which requires biotransformation to exhibit its effect. , 1980). In other cases, the duration of action characterizes the antagonism. A short-acting drug may antagonize the action of a long-acting drug with a similar effect. Pertinent examples in this respect are the antagonism between tetrabenazine and reserpine, two releasers of monoamines (Manara and Garattini, 1967) and tranylcypromine and iproniazide, two mono amine oxidase inhibitors (Pletscher and Besendorf, 1959).

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