Download Alzheimer's disease and related disorders annual, 2002 by Jeffrey L Cummings, Serge Gauthier PDF

By Jeffrey L Cummings, Serge Gauthier

Given the advance of recent healing suggestions and items, Serge Gauthier and Jeffrey Cummings have compiled an inventory of up to date subject matters on the way to be of curiosity basically to neurologists targeting Alzheimer's ailment, and in addition to psychiatrists and geriatricians. The individuals, all revered of their subspecialties, have written updated, comprehensively referenced chapters which should supply assistance in addition to stimulate dialogue on the place present remedy is heading.

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J Neurosci Res 1999; 58:167–190. 37. Roy N, Deveraux QL, Takahashi R et al. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases. Embo J 1997; 16:6914– 6925. 38. LeBlanc A, Liu H, Goodyer C et al. Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer’s disease. J Biol Chem 1999; 274:23426–23436. 39. Seidl R, Bajo M, Bohm K et al. Neuronal apoptosis inhibitory protein (NAIP)-like immunoreactivity in 33 brains of adult patients with Down syndrome. J Neural Transm Suppl 1999; 57:283–291.

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Levels of IL-1β are markedly elevated in AD and it is possible that a related mechanism also contributes to apoptosis in this disease. 55 Treatment of neurons with this agent results in caspase-3 dependent PCD (Troy et al, in preparation). We know that caspase-3 inhibition does not protect from acute Aβ toxicity, suggesting Aβ-induced increases in HNE do not occur on the time scale of the culture experiments or that sufficient HNE levels are not reached. While we do not know precisely how these data fit into the pathogenesis of AD, a hypothetical model of the ‘Natural history of Alzheimer’s disease’ can provide a framework for the testing of ideas and can suggest targets for therapeutic intervention.

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