Download AIDS Pathogenesis by Angélique Van’t Wout, Richard A. Koup, William A. Paxton PDF

By Angélique Van’t Wout, Richard A. Koup, William A. Paxton (auth.), Hanneke Schuitemaker, Frank Miedema (eds.)

Infection with the human immunodeficiency virus is characterised through the destruction of the host immune procedure as additionally mirrored by way of a revolutionary lack of CD4-positive T-cells. This ultimately leads to the host's incapability to house opportunistic infections and the immune surveillance of tumors, a scientific prestige referred to as the received Immunodeficiency Syndrome (AIDS).
The booklet AIDS Pathogenesis offers the reader with a whole evaluate of the medical process HIV-1 an infection. It describes the scientific elements of basic an infection, the various scientific results of HIV-1 an infection, and techniques for anti-viral therapy. additionally, extra primary elements of HIV-1 an infection are reviewed. those contain the biology of the virus and the radical insights in AIDS pathogenesis. not just is the importance of an HIV-specific mobile and humoral immune reaction mentioned, but additionally the potential incapability of the grownup human host to accommodate T-cell destruction. eventually, the booklet discusses the at the moment used laboratory markers that let for tracking of the medical process infection.

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3. Strain Selection during Transmission A single strain of HIV is transmitted in general [113], although co-infection has been described in individual cases of sexual and transfusional transmission [15, 115]. Transmitted strains tend to have an non-syncytium-inducing (NSI) phenotype [48, 87] but may not be the most common strain in the blood or semen of the source subject [113,114], suggesting that one or more structural, viral or immunologic feature may influence strain transmission. 4. Viral Phenotype The ability of HN to be syncytium-inducing (SI) in MT-2 cell culture correlates with a worse prognosis [80].

Assay for serum HIV-1 p24 antigen is essential if the differential diagnosis includes primary HIV infection. The assay is easy, cheap, widely available, sensitive and specific and can be performed in a few hours. False-positive p24 antigen tests rarely occur, however, and the specificity should be confirmed by neutralisation. To minimise the risk of transfusion-associated HIV infection (estimated at 1 in 493000 in the United States), blood banks in the United States now screen for HIV antibodies and p24 antigen in the one assay [88].

Intern. Med. 125 (1996), 257-264. H. : The risk of transfusiontransmitted viral infections: the retrovirus epidemiology donor study, New Engl. J. Med. 334 (1996), 1685-1690. Primary HIV Infection 89. 90. 91. 92. 93. 94. 95. 96. 97. 98. 99. 100. 101. 102. 103. 104. 105. 106. 107. lOS. 109. 110. Ill. 112. 113. , et al: Acute HIV-1 infection: Clinical and biological study of 12 patients, J. Acq. Immune Def Syndr. Human Retrovir. 3 (1990), 260-265. , et al: Cytokine network and acute HIV-1 infection, AIDS 7 (1993), 625-631.

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