By E. Lütjen-Drecoll
The phenomenon of getting older is characterised by means of a variety of degenerative adjustments, which differentially have an effect on the hugely really expert buildings in the eye, reminiscent of the only mobile lens, the brain-derived retina and the connective tissue of the uvea and sclera. consequently, the attention can function an outstanding version approach to review age-related degenerative ailments. an outline article bargains with the molecular biology of alpha-B-crystallin, and unique articles provide additional perception into the distribution and attainable sensible importance of nonlenticular alpha-B-crystallin. Retinal transplantation experiences which may finally result in treatment for tapetoretinal degeneration and age-related macular degeneration are mentioned. extra, components that impression the improvement of the retinal tissues are investigated. And one other review examines cells of the deep lens fibers. This designated factor is an in-depth resource of knowledge to ophthalmologists in learn and perform.
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Additional info for Aging and Age Related Ocular Diseases (Ophthalmologica, 1)
23] have shown that, as in smooth muscle, substances that contract trabecular meshwork elevate cytosolic calcium. Thus, it can by now be seen as evident that trabecular meshwork resembles smooth muscle, with the potential for regulating intraocular pressure. The search for specific pharmacological agents that interact with channels, transporters, receptors or other proteins in the signalling cascade leading to changes in trabecular meshwork contractility is thus a worthwhile undertaking, potentially leading to a better and more specific pharmacological control of intraocular pressure.
Five different cell lines of human trabecular meshwork displayed membrane voltages in the range of –44 to –63 mV , cell puncture experiments on cells from a primary culture of human cells fell within that range. All of these voltages are more positive than the equilibrium potential for potassium due to the flux of other ions like sodium, calcium or chloride across the cell membrane. This fact was confirmed by changing the concentration of extracellular potassium. This maneuver resulted in a depolarization of the cells which depended on the concentration of potassium applied (fig.
31 Duhamel RC, Johnson DA: Use of nonfat dry milk to block nonspecific nuclear and membrane staining by avidin conjugates. J Histochem Cytochem 1985;33:711–714. 32 Skoff RP, Vaughn JE: An autoradiographic study of cellular proliferation in degenerating rat optic nerve. J Comp Neurol 1971;141:133– 156. 33 Mansour H, Asher R, Dahl D, Labkovsky B, Perides G, Bignami A: Permissive and nonpermissive reactive astrocytes: Immunofluorescence study with antibodies to the glial hyaluronate-binding protein.