By Prof. K. A. Jellinger MD (auth.), Prof. Dr. Kurt A. Jellinger, Prof. Dr. Reinhold Schmidt, Dr. Manfred Windisch (eds.)
Epidemiological reviews, glossy medical, neuroimaging, neuropsychological, molecular organic, and genetic reviews have significantly improved our wisdom approximately getting old procedures of the human mind, its sequelae, diagnostic, and healing probabilities and boundaries. as well as Alzheimer's affliction and different degenerative dementias, the effect of cerebrovascular lesions and their danger elements within the pathogenesis of cognitive problems of the elderly are more and more said, and the popularity of light cognitive impairment as a common preliminary degree of constructing dementia is turning into an more and more vital diagnostic and healing challenge. The integrated papers have been offered on the seventh foreign Symposium in Graz, Sept. 2001 and provides a well timed evaluation of the present and destiny innovations of pathogenesis, prognosis, and therapy suggestions of pathological mind growing older and dementias, early reputation of gentle cognitive impairment and destiny possiblities of prevention of dementing processes.
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Additional resources for Ageing and Dementia Current and Future Concepts
2000). Further development of these methods will hopefully lead to more uniform and int erpretable measures of WML. Cut-offs of WML distribution Most studies, even if they rate lesions (semi-) quantitatively, use a cut-off point when th ey report prevalences of WML. This implies that lesion severity is dichotomised somewhere along its spectrum. , 10 " . > : -', "':- ... :'-- -- " ............... 0 0 2 3 4 5 6 .... ... _- ----- 7 . . . 8 ". , 9 Periventricular white matter lesions grade a 80 0/0 70 - - 60-70 years 60 - - - - 70-80 years 50 - - - - - -·80-90 years 40 30 20 ' .
A. Jellinger et al. ), Ageing and Dementia Current and Future Concepts © Springer-Verlag/Wein 2002 48 R. Schmidt et al. natural course of cerebral small vessel disease are needed as they will allow to better judge the clinical importance of this type of brain damage. Associations of progression with specific risk factors will probably enable to identify high risk groups as targets for therapeutical intervention. Frequency of progression of small vessel disease related brain abnormalities To the present the Austrian Stroke Prevention Study is the only investigation that sytematically explored the frequency and risk factors of progression of cerebral small vessel disease.
2. , 2001). In the CHS the sex differences remained significant after adjusting for age. However, in the ARIC no significant sex difference was found. Silent lacunar infarcts were significantly more often seen in women in the CHS and Rotterdam Scan Study, adjusted for age. Ethnicity Reports on ethnic differences in WML and silent lacunar infarcts prevalences are scarce and equivocal. Prevalence of any WML was significantly lower in Afro-Americans (81%) than in Caucasians (90%) in the ARIC study, adjusted for age and sex.